Preparation and Characterization of Pazopanib Hydrochloride-Loaded Four-Component Self-Nanoemulsifying Drug Delivery Systems Preconcentrate for Enhanced Solubility and Dissolution

• Principais autores: Seung Ah Choi (Autor), Eun Ji Park (Autor), Jun Hak Lee (Autor), Kyoung Ah Min (Autor), Sung Tae Kim (Autor), Dong-Jin Jang (Autor), Han-Joo Maeng (Autor), Sung Giu Jin (Autor), Kwan Hyung Cho (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2022-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The aim of this study was to develop a four-component self-nanoemulsifying drug delivery system (FCS) to enhance the solubility and dissolution of pazopanib hydrochloride (PZH). In the solubility test, PZH showed a highly pH-dependent solubility (pH 1.2 > water >> pH 4.0 and pH 6.8) and was...