Preparation and Characterization of Pazopanib Hydrochloride-Loaded Four-Component Self-Nanoemulsifying Drug Delivery Systems Preconcentrate for Enhanced Solubility and Dissolution

• Main Authors: Seung Ah Choi (Author), Eun Ji Park (Author), Jun Hak Lee (Author), Kyoung Ah Min (Author), Sung Tae Kim (Author), Dong-Jin Jang (Author), Han-Joo Maeng (Author), Sung Giu Jin (Author), Kwan Hyung Cho (Author)
• Format: Book
• Published: MDPI AG, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this study was to develop a four-component self-nanoemulsifying drug delivery system (FCS) to enhance the solubility and dissolution of pazopanib hydrochloride (PZH). In the solubility test, PZH showed a highly pH-dependent solubility (pH 1.2 > water >> pH 4.0 and pH 6.8) and was...