Ebola GP-specific monoclonal antibodies protect mice and guinea pigs from lethal Ebola virus infection.

• Main Authors: Xiangguo Qiu (Author), Lisa Fernando (Author), P Leno Melito (Author), Jonathan Audet (Author), Heinz Feldmann (Author), Gary Kobinger (Author), Judie B Alimonti (Author), Steven M Jones (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ebola virus (EBOV) causes acute hemorrhagic fever in humans and non-human primates with mortality rates up to 90%. So far there are no effective treatments available. This study evaluates the protective efficacy of 8 monoclonal antibodies (MAbs) against Ebola glycoprotein in mice and guinea pigs. Im...