Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced β-cell damage and pancreatic Glp-1 gene therapy

• Main Authors: Jason M. Tonne (Author), Toshie Sakuma (Author), Michael C. Deeds (Author), Miguel Munoz-Gomez (Author), Michael A. Barry (Author), Yogish C. Kudva (Author), Yasuhiro Ikeda (Author)
• Format: Bog
• Udgivet: The Company of Biologists, 2013-09-01T00:00:00Z.
• Fag: article
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SUMMARY Streptozotocin (STZ), a glucosamine-nitrosourea compound, has potent genotoxic effects on pancreatic β-cells and is frequently used to induce diabetes in experimental animals. Glucagon-like peptide-1 (GLP-1) has β-cell protective effects and is known to preserve β-cells from STZ treatment. I...