Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced β-cell damage and pancreatic Glp-1 gene therapy

• Үндсэн зохиолчид: Jason M. Tonne (Зохиогч), Toshie Sakuma (Зохиогч), Michael C. Deeds (Зохиогч), Miguel Munoz-Gomez (Зохиогч), Michael A. Barry (Зохиогч), Yogish C. Kudva (Зохиогч), Yasuhiro Ikeda (Зохиогч)
• Формат: Ном
• Хэвлэсэн: The Company of Biologists, 2013-09-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

SUMMARY Streptozotocin (STZ), a glucosamine-nitrosourea compound, has potent genotoxic effects on pancreatic β-cells and is frequently used to induce diabetes in experimental animals. Glucagon-like peptide-1 (GLP-1) has β-cell protective effects and is known to preserve β-cells from STZ treatment. I...