Peripheral administration of interleukin-13 reverses inflammatory macrophage and tactile allodynia in mice with partial sciatic nerve ligation

• Main Authors: Norikazu Kiguchi (Author), Haruka Sakaguchi (Author), Yui Kadowaki (Author), Fumihiro Saika (Author), Yohji Fukazawa (Author), Shinsuke Matsuzaki (Author), Shiroh Kishioka (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Inflammatory macrophages play a fundamental role in neuropathic pain. In this study, we demonstrate the effects of peripheral interleukin-13 (IL-13) on neuropathic pain after partial sciatic nerve (SCN) ligation (PSL) in mice. IL-13 receptor α1 was upregulated in accumulating macrophages in the inju...