Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain

• Автори: Katharina Holl (Автор), Dirk Schepmann (Автор), Steffen Fischer (Автор), Friedrich-Alexander Ludwig (Автор), Achim Hiller (Автор), Cornelius K. Donat (Автор), Winnie Deuther-Conrad (Автор), Peter Brust (Автор), Bernhard Wünsch (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2014-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Sharpless asymmetric dihydroxylation of styrene derivative 6 afforded chiral triols (R)-7 and (S)-7, which were cyclized with tosyl chloride in the presence of Bu2SnO to provide 2-benzopyrans (R)-4 and (S)-4 with high regioselectivity. The additional hydroxy moiety in the 4-position was exploited fo...