Breast cancer in patients with germline TP53 pathogenic variants have typical tumour characteristics: the Cohort study of TP53 carrier early onset breast cancer (COPE study)

• Main Authors: Kate Packwood (Author), Guy Martland (Author), Matthew Sommerlad (Author), Emily Shaw (Author), Karwan Moutasim (Author), Gareth Thomas (Author), Adrian C Bateman (Author), Louise Jones (Author), Linda Haywood (Author), D Gareth Evans (Author), Jillian M Birch (Author), Ohud A Alsalmi (Author), Alex Henderson (Author), Nicola Poplawski (Author), Diana M Eccles (Author)
• Format: Book
• Published: Wiley, 2019-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Germline TP53 pathogenic variants are rare but associated with a high risk of cancer; they are often identified in the context of clinically diagnosed Li-Fraumeni syndrome predisposing to a range of young onset cancers including sarcomas and breast cancer. The study aim was to conduct a det...