Breast cancer in patients with germline TP53 pathogenic variants have typical tumour characteristics: the Cohort study of TP53 carrier early onset breast cancer (COPE study)

• Автори: Kate Packwood (Автор), Guy Martland (Автор), Matthew Sommerlad (Автор), Emily Shaw (Автор), Karwan Moutasim (Автор), Gareth Thomas (Автор), Adrian C Bateman (Автор), Louise Jones (Автор), Linda Haywood (Автор), D Gareth Evans (Автор), Jillian M Birch (Автор), Ohud A Alsalmi (Автор), Alex Henderson (Автор), Nicola Poplawski (Автор), Diana M Eccles (Автор)
• Формат: Книга
• Опубліковано: Wiley, 2019-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Germline TP53 pathogenic variants are rare but associated with a high risk of cancer; they are often identified in the context of clinically diagnosed Li-Fraumeni syndrome predisposing to a range of young onset cancers including sarcomas and breast cancer. The study aim was to conduct a det...