Improving the stability of 11C-labeled L-methionine with ascorbate

• Glavni autori: Michael Woods (Autor), Leo Leung (Autor), Kari Frantzen (Autor), Jennifer G. Garrick (Autor), Zhengxing Zhang (Autor), Chengcheng Zhang (Autor), Wade English (Autor), Don Wilson (Autor), François Bénard (Autor), Kuo-Shyan Lin (Autor)
• Format: Knjiga
• Izdano: SpringerOpen, 2017-10-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Abstract Background Carbon-11 labeled L-methionine (11C-MET) is a popular tracer used in the clinic for imaging brain tumors with positron emission tomography. However, the stability of 11C-MET in its final formulation is not well documented in literature. Recently, we observed fast degradation of H...