Improving the stability of 11C-labeled L-methionine with ascorbate

• Main Authors: Michael Woods (Author), Leo Leung (Author), Kari Frantzen (Author), Jennifer G. Garrick (Author), Zhengxing Zhang (Author), Chengcheng Zhang (Author), Wade English (Author), Don Wilson (Author), François Bénard (Author), Kuo-Shyan Lin (Author)
• Format: Book
• Published: SpringerOpen, 2017-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Carbon-11 labeled L-methionine (11C-MET) is a popular tracer used in the clinic for imaging brain tumors with positron emission tomography. However, the stability of 11C-MET in its final formulation is not well documented in literature. Recently, we observed fast degradation of H...