OTX2 exhibits cell-context-dependent effects on cellular and molecular properties of human embryonic neural precursors and medulloblastoma cells

• Main Authors: Ravinder Kaur (Author), Christopher Aiken (Author), Ludivine Coudière Morrison (Author), Radhika Rao (Author), Marc R. Del Bigio (Author), Shravanti Rampalli (Author), Tamra Werbowetski-Ogilvie (Author)
• Format: Book
• Published: The Company of Biologists, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Medulloblastoma (MB) is the most common malignant primary pediatric brain tumor and is currently divided into four subtypes based on different genomic alterations, gene expression profiles and response to treatment: WNT, Sonic Hedgehog (SHH), Group 3 and Group 4. This extensive heterogeneity has mad...