Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1

• मुख्य लेखकों: Hengru Guo (लेखक), Ying Xin (लेखक), Saifei Wang (लेखक), Xiaoning Zhang (लेखक), Yanqi Ren (लेखक), Bo Qiao (लेखक), Hongjiang Li (लेखक), Jing Wu (लेखक), Xiao Hao (लेखक), Lijun Xu (लेखक), Yushan Yan (लेखक), Haohao Zhang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2024-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Imbalance in energy regulation is a major cause of insulin resistance and diabetes. Melanocortin-4 receptor (MC4R) signaling at specific sites in the central nervous system has synergistic but non-overlapping functions. However, the mechanism by which MC4R in the arcuate nucleus...