Hypothalamic POMC neuron-specific knockout of MC4R affects insulin sensitivity by regulating Kir2.1

• Main Authors: Hengru Guo (Author), Ying Xin (Author), Saifei Wang (Author), Xiaoning Zhang (Author), Yanqi Ren (Author), Bo Qiao (Author), Hongjiang Li (Author), Jing Wu (Author), Xiao Hao (Author), Lijun Xu (Author), Yushan Yan (Author), Haohao Zhang (Author)
• Format: Book
• Published: BMC, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Imbalance in energy regulation is a major cause of insulin resistance and diabetes. Melanocortin-4 receptor (MC4R) signaling at specific sites in the central nervous system has synergistic but non-overlapping functions. However, the mechanism by which MC4R in the arcuate nucleus...