Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies

• Main Authors: Doaa Samaha (Author), Sawsan Mahmoud (Author), Mosaad Sayed Mohamed (Author), Rokaia S. Abdullah (Author), Nageh A. Abou Taleb (Author), Tomohisa Nagamatsu (Author), Hamed I. Ali (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study describes the development of novel alloxazine analogues as potent antitumor agents with enhanced selectivity for tumour cells. Twenty-nine out of 45 newly compounds were investigated in vitro for their growth inhibitory activities, against two human tumour cell lines, namely, the human T-...