Novel alloxazine analogues: design, synthesis, and antitumour efficacy enhanced by kinase screening, molecular docking, and ADME studies

• 主要な著者: Doaa Samaha (著者), Sawsan Mahmoud (著者), Mosaad Sayed Mohamed (著者), Rokaia S. Abdullah (著者), Nageh A. Abou Taleb (著者), Tomohisa Nagamatsu (著者), Hamed I. Ali (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

This study describes the development of novel alloxazine analogues as potent antitumor agents with enhanced selectivity for tumour cells. Twenty-nine out of 45 newly compounds were investigated in vitro for their growth inhibitory activities, against two human tumour cell lines, namely, the human T-...