Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators

• मुख्य लेखकों: Roberto Sabbadini (लेखक), Emanuela Pesce (लेखक), Alice Parodi (लेखक), Eleonora Mustorgi (लेखक), Santina Bruzzone (लेखक), Nicoletta Pedemonte (लेखक), Monica Casale (लेखक), Enrico Millo (लेखक), Elena Cichero (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2021-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Cystic fibrosis (CF) is caused by different mutations related to the cystic fibrosis transmembrane regulator protein (CFTR), with F508del being the most common. Pioneering the development of CFTR modulators, thanks to the development of effective correctors or potentiators, more recent studies deepl...