Probing Allosteric Hsp70 Inhibitors by Molecular Modelling Studies to Expedite the Development of Novel Combined F508del CFTR Modulators

• Main Authors: Roberto Sabbadini (Author), Emanuela Pesce (Author), Alice Parodi (Author), Eleonora Mustorgi (Author), Santina Bruzzone (Author), Nicoletta Pedemonte (Author), Monica Casale (Author), Enrico Millo (Author), Elena Cichero (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cystic fibrosis (CF) is caused by different mutations related to the cystic fibrosis transmembrane regulator protein (CFTR), with F508del being the most common. Pioneering the development of CFTR modulators, thanks to the development of effective correctors or potentiators, more recent studies deepl...