Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation

• Main Authors: Xuefei Yu (Author), Catherine Arden (Author), Rolando Berlinguer-Palmini (Author), Chun Chen (Author), Carla Bradshaw (Author), Anna LM Smith (Author), Julia Whitehall (Author), Michael White (Author), Scott Anderson (Author), Nicole Kattner (Author), James Shaw (Author), Doug Turnbull (Author), Laura C Greaves (Author), Mark Walker (Author)
• Format: Book
• Published: Elsevier, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: There is strong evidence that mitochondrial DNA mutations and mitochondrial dysfunction play a role in diabetes pathogenesis. The homozygous knock-in mtDNA mutator mouse is a model of premature aging due to the accumulation of mitochondrial DNA mutations. We used this mouse model to inves...