Mitochondrial complex I subunit deficiency promotes pancreatic α-cell proliferation

• 主要な著者: Xuefei Yu (著者), Catherine Arden (著者), Rolando Berlinguer-Palmini (著者), Chun Chen (著者), Carla Bradshaw (著者), Anna LM Smith (著者), Julia Whitehall (著者), Michael White (著者), Scott Anderson (著者), Nicole Kattner (著者), James Shaw (著者), Doug Turnbull (著者), Laura C Greaves (著者), Mark Walker (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2022-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Objective: There is strong evidence that mitochondrial DNA mutations and mitochondrial dysfunction play a role in diabetes pathogenesis. The homozygous knock-in mtDNA mutator mouse is a model of premature aging due to the accumulation of mitochondrial DNA mutations. We used this mouse model to inves...