Seed-mediated RNA interference of androgen signaling and survival networks induces cell death in prostate cancer cells
Resistance to anti-androgen therapy in prostate cancer (PCa) is often driven by genetic and epigenetic aberrations in the androgen receptor (AR) and coregulators that maintain androgen signaling activity. We show that specific small RNAs downregulate expression of multiple essential and androgen rec...
Saved in:
Main Authors: | Joshua M. Corbin (Author), Constantin Georgescu (Author), Jonathan D. Wren (Author), Chao Xu (Author), Adam S. Asch (Author), Maria J. Ruiz-Echevarría (Author) |
---|---|
Format: | Book |
Published: |
Elsevier,
2021-06-01T00:00:00Z.
|
Subjects: | |
Online Access: | Connect to this object online. |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
An unbiased seed-based RNAi selection screen identifies small RNAs that inhibit androgen signaling and prostate cancer cell growth
by: Joshua M. Corbin, et al.
Published: (2023) -
The Androgen Receptor Bridges Stem Cell-Associated Signaling Nodes in Prostate Stem Cells
by: Alastair H. Davies, et al.
Published: (2016) -
Characterization of a Prostate- and Prostate Cancer-Specific Circular RNA Encoded by the Androgen Receptor Gene
by: Jindan Luo, et al.
Published: (2019) -
Cytostatic Action of Novel Histone Deacetylase Inhibitors in Androgen Receptor-Null Prostate Cancer Cells
by: Zohaib Rana, et al.
Published: (2021) -
Progressive accumulation of cytoplasmic aggregates in PRPF31 retinal pigment epithelium cells interferes with cell survival
by: Maria Georgiou, et al.
Published: (2022)