Silencing of microRNA-106b-5p prevents doxorubicin-mediated cardiotoxicity through modulation of the PR55α/YY1/sST2 signaling axis

Clinical use of doxorubicin (Dox), an anthracycline with potent anti-tumor effects, is limited because of its highly chemotherapy-induced cardiotoxicity (CIC). After myocardial infarction (MI), we have recently identified Yin Yang-1 (YY1) and histone deacetylase 4 (HDAC4) as two factors involved in...

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Main Authors: Antonio Lax (Author), Fernando Soler (Author), Maria Josefa Fernandez del Palacio (Author), Silvia Pascual-Oliver (Author), Miriam Ruiz Ballester (Author), Jose Javier Fuster (Author), Domingo Pascual-Figal (Author), Maria del Carmen Asensio-Lopez (Author)
Format: Book
Published: Elsevier, 2023-06-01T00:00:00Z.
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