Silencing of microRNA-106b-5p prevents doxorubicin-mediated cardiotoxicity through modulation of the PR55α/YY1/sST2 signaling axis

• المؤلفون الرئيسيون: Antonio Lax (مؤلف), Fernando Soler (مؤلف), Maria Josefa Fernandez del Palacio (مؤلف), Silvia Pascual-Oliver (مؤلف), Miriam Ruiz Ballester (مؤلف), Jose Javier Fuster (مؤلف), Domingo Pascual-Figal (مؤلف), Maria del Carmen Asensio-Lopez (مؤلف)
• التنسيق: كتاب
• منشور في: Elsevier, 2023-06-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Clinical use of doxorubicin (Dox), an anthracycline with potent anti-tumor effects, is limited because of its highly chemotherapy-induced cardiotoxicity (CIC). After myocardial infarction (MI), we have recently identified Yin Yang-1 (YY1) and histone deacetylase 4 (HDAC4) as two factors involved in...