Silencing of microRNA-106b-5p prevents doxorubicin-mediated cardiotoxicity through modulation of the PR55α/YY1/sST2 signaling axis

• Autori principali: Antonio Lax (Autore), Fernando Soler (Autore), Maria Josefa Fernandez del Palacio (Autore), Silvia Pascual-Oliver (Autore), Miriam Ruiz Ballester (Autore), Jose Javier Fuster (Autore), Domingo Pascual-Figal (Autore), Maria del Carmen Asensio-Lopez (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2023-06-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Clinical use of doxorubicin (Dox), an anthracycline with potent anti-tumor effects, is limited because of its highly chemotherapy-induced cardiotoxicity (CIC). After myocardial infarction (MI), we have recently identified Yin Yang-1 (YY1) and histone deacetylase 4 (HDAC4) as two factors involved in...