Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system

Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system

RNA therapeutics are an emerging, powerful class of drugs with potential applications in a wide range of disorders. A central challenge in their development is the lack of clear pharmacokinetic (PK)-pharmacodynamic relationship, in part due to the significant delay between the kinetics of RNA delive...

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Main Authors: Hamideh Parhiz (Author), Vladimir V. Shuvaev (Author), Qin Li (Author), Tyler E. Papp (Author), Awurama A. Akyianu (Author), Ruiqi Shi (Author), Amir Yadegari (Author), Hamna Shahnawaz (Author), Sean C. Semple (Author), Barbara L. Mui (Author), Drew Weissman (Author), Vladimir R. Muzykantov (Author), Patrick M. Glassman (Author)
Format: Book
Published: Elsevier, 2024-06-01T00:00:00Z.
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