Physiologically based modeling of LNP-mediated delivery of mRNA in the vascular system

• Váldodahkkit: Hamideh Parhiz (Dahkki), Vladimir V. Shuvaev (Dahkki), Qin Li (Dahkki), Tyler E. Papp (Dahkki), Awurama A. Akyianu (Dahkki), Ruiqi Shi (Dahkki), Amir Yadegari (Dahkki), Hamna Shahnawaz (Dahkki), Sean C. Semple (Dahkki), Barbara L. Mui (Dahkki), Drew Weissman (Dahkki), Vladimir R. Muzykantov (Dahkki), Patrick M. Glassman (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2024-06-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

RNA therapeutics are an emerging, powerful class of drugs with potential applications in a wide range of disorders. A central challenge in their development is the lack of clear pharmacokinetic (PK)-pharmacodynamic relationship, in part due to the significant delay between the kinetics of RNA delive...