Effects of TAK-480, a Novel Tachykinin NK2-Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid-Induced Defecation in Guinea Pigs

TAK-480, 4-(difluoromethoxy)-N-((1R,2S)-2-(((3aR,4R,9bR)-4-(methoxymethyl)-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK2-receptor antagonist. In this study, we investigated its antagonistic activity and efficacy in animal models of v...

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Main Authors: Takahiro Tanaka (Author), Akiko Tanaka (Author), Akihiro Nakamura (Author), Kozo Matsushita (Author), Akio Imanishi (Author), Shiho Matsumoto-Okano (Author), Nobuhiro Inatomi (Author), Kasei Miura (Author), Masao Toyoda (Author), Gaku Mizojiri (Author), Yasuhiro Tsukimi (Author)
Format: Book
Published: Elsevier, 2012-01-01T00:00:00Z.
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