Effects of TAK-480, a Novel Tachykinin NK2-Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid-Induced Defecation in Guinea Pigs

• Glavni autori: Takahiro Tanaka (Autor), Akiko Tanaka (Autor), Akihiro Nakamura (Autor), Kozo Matsushita (Autor), Akio Imanishi (Autor), Shiho Matsumoto-Okano (Autor), Nobuhiro Inatomi (Autor), Kasei Miura (Autor), Masao Toyoda (Autor), Gaku Mizojiri (Autor), Yasuhiro Tsukimi (Autor)
• Format: Knjiga
• Izdano: Elsevier, 2012-01-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

TAK-480, 4-(difluoromethoxy)-N-((1R,2S)-2-(((3aR,4R,9bR)-4-(methoxymethyl)-2, 3,3a,4,5,9b-hexahydro-1H-pyrrolo[3,2-c]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK2-receptor antagonist. In this study, we investigated its antagonistic activity and efficacy in animal models of v...