Pharmacogenetics of tenofovir and emtricitabine penetration into cerebrospinal fluid

• Main Authors: Eric H. Decloedt (Author), Phumla Z. Sinxadi (Author), Lubbe Wiesner (Author), John A. Joska (Author), David W. Haas (Author), Gary Maartens (Author)
• Format: Book
• Published: AOSIS, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Blood-cerebrospinal fluid (CSF) barrier transporters affect the influx and efflux of drugs. The antiretrovirals tenofovir and emtricitabine may be substrates of blood-brain barrier (BBB) and blood-CSF barrier transporters, but data are limited regarding the pharmacogenetics and pharmacok...