Development of a Virtual Chinese Pediatric Population Physiological Model Targeting Specific Metabolism and Kidney Elimination Pathways

• Main Authors: Xueting Yao (Author), Xuanlin Liu (Author), Siqi Tu (Author), Xiaobei Li (Author), Zihan Lei (Author), Zhe Hou (Author), Zhiheng Yu (Author), Cheng Cui (Author), Zhongqi Dong (Author), Farzaneh Salem (Author), Haiyan Li (Author), Dongyang Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Physiologically based pharmacokinetic (PBPK) modeling and simulating may be a powerful tool in predicting drug behaviors in specific populations. It is a mathematical model that relates the pharmacokinetic (PK) profile of a compound with human anatomical characteristics, physiological ch...