Development of a Virtual Chinese Pediatric Population Physiological Model Targeting Specific Metabolism and Kidney Elimination Pathways

• Автори: Xueting Yao (Автор), Xuanlin Liu (Автор), Siqi Tu (Автор), Xiaobei Li (Автор), Zihan Lei (Автор), Zhe Hou (Автор), Zhiheng Yu (Автор), Cheng Cui (Автор), Zhongqi Dong (Автор), Farzaneh Salem (Автор), Haiyan Li (Автор), Dongyang Liu (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Background: Physiologically based pharmacokinetic (PBPK) modeling and simulating may be a powerful tool in predicting drug behaviors in specific populations. It is a mathematical model that relates the pharmacokinetic (PK) profile of a compound with human anatomical characteristics, physiological ch...