A Physiologically Based Pharmacokinetic Model of Ketoconazole and Its Metabolites as Drug-Drug Interaction Perpetrators

• Главные авторы: Fatima Zahra Marok (Автор), Jan-Georg Wojtyniak (Автор), Laura Maria Fuhr (Автор), Dominik Selzer (Автор), Matthias Schwab (Автор), Johanna Weiss (Автор), Walter Emil Haefeli (Автор), Thorsten Lehr (Автор)
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• Опубликовано: MDPI AG, 2023-02-01T00:00:00Z.
• Предметы: article
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The antifungal ketoconazole, which is mainly used for dermal infections and treatment of Cushing's syndrome, is prone to drug-food interactions (DFIs) and is well known for its strong drug-drug interaction (DDI) potential. Some of ketoconazole's potent inhibitory activity can be attributed...