Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

• প্রধান লেখক: Yijia Yang (লেখক), Shibo Sun (লেখক), Weiping Xu (লেখক), Yue Zhang (লেখক), Rui Yang (লেখক), Kun Ma (লেখক), Jie Zhang (লেখক), Jianqiang Xu (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2022-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Piperlongumine, a natural alkaloid substance extracted from the fruit of the long pepper (<i>Piper longum Linn</i>.), is known to inhibit the cytosolic thioredoxin reductase (TXNRD1 or TrxR1) and selectively kill cancer cells. However, the details and mechanism of the inhibition by piper...