Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

• Asıl Yazarlar: Yijia Yang (Yazar), Shibo Sun (Yazar), Weiping Xu (Yazar), Yue Zhang (Yazar), Rui Yang (Yazar), Kun Ma (Yazar), Jie Zhang (Yazar), Jianqiang Xu (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Piperlongumine, a natural alkaloid substance extracted from the fruit of the long pepper (<i>Piper longum Linn</i>.), is known to inhibit the cytosolic thioredoxin reductase (TXNRD1 or TrxR1) and selectively kill cancer cells. However, the details and mechanism of the inhibition by piper...