Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

• Egile Nagusiak: Yijia Yang (Egilea), Shibo Sun (Egilea), Weiping Xu (Egilea), Yue Zhang (Egilea), Rui Yang (Egilea), Kun Ma (Egilea), Jie Zhang (Egilea), Jianqiang Xu (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-04-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Piperlongumine, a natural alkaloid substance extracted from the fruit of the long pepper (<i>Piper longum Linn</i>.), is known to inhibit the cytosolic thioredoxin reductase (TXNRD1 or TrxR1) and selectively kill cancer cells. However, the details and mechanism of the inhibition by piper...