Piperlongumine Inhibits Thioredoxin Reductase 1 by Targeting Selenocysteine Residues and Sensitizes Cancer Cells to Erastin

• 主要な著者: Yijia Yang (著者), Shibo Sun (著者), Weiping Xu (著者), Yue Zhang (著者), Rui Yang (著者), Kun Ma (著者), Jie Zhang (著者), Jianqiang Xu (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2022-04-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Piperlongumine, a natural alkaloid substance extracted from the fruit of the long pepper (<i>Piper longum Linn</i>.), is known to inhibit the cytosolic thioredoxin reductase (TXNRD1 or TrxR1) and selectively kill cancer cells. However, the details and mechanism of the inhibition by piper...