Comparative metabolism and tolerability of racemic primaquine and its enantiomers in human volunteers during 7-day administration

• Main Authors: Washim Khan (Author), Yan-Hong Wang (Author), Narayan D. Chaurasiya (Author), N. P. Dhammika Nanayakkara (Author), H. M. Bandara Herath (Author), Kerri A. Harrison (Author), Gray Dale (Author), Donald A. Stanford (Author), Eric P. Dahl (Author), James D. McChesney (Author), Waseem Gul (Author), Mahmoud A. ElSohly (Author), David Jollow (Author), Babu L. Tekwani (Author), Larry A. Walker (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Primaquine (PQ) is an 8-aminoquinoline antimalarial, active against dormant Plasmodium vivax hypnozoites and P. falciparum mature gametocytes. PQ is currently used for P. vivax radical cure and prevention of malaria transmission. PQ is a racemic drug and since the metabolism and pharmacology of PQ&#...