Molnupiravir: Mechanism of action, clinical, and translational science

• Main Authors: Brian M. Maas (Author), Julie Strizki (Author), Randy R. Miller (Author), Sushma Kumar (Author), Michelle Brown (Author), Matthew G. Johnson (Author), Mickie Cheng (Author), Carisa De Anda (Author), Matthew L. Rizk (Author), Julie A. Stone (Author)
• Format: Book
• Published: Wiley, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Molnupiravir is an oral prodrug of the broadly active, antiviral ribonucleoside analog N‐hydroxycytidine (NHC). The primary circulating metabolite NHC is taken up into cells and phosphorylated to NHC‐triphosphate (NHC‐TP). NHC‐TP serves as a competitive substrate for viral RNA‐dependent RNA...