Molnupiravir: Mechanism of action, clinical, and translational science

• Главные авторы: Brian M. Maas (Автор), Julie Strizki (Автор), Randy R. Miller (Автор), Sushma Kumar (Автор), Michelle Brown (Автор), Matthew G. Johnson (Автор), Mickie Cheng (Автор), Carisa De Anda (Автор), Matthew L. Rizk (Автор), Julie A. Stone (Автор)
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• Опубликовано: Wiley, 2024-02-01T00:00:00Z.
• Предметы: article
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Abstract Molnupiravir is an oral prodrug of the broadly active, antiviral ribonucleoside analog N‐hydroxycytidine (NHC). The primary circulating metabolite NHC is taken up into cells and phosphorylated to NHC‐triphosphate (NHC‐TP). NHC‐TP serves as a competitive substrate for viral RNA‐dependent RNA...