Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase

N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) hydrolase that catalyses the intracellular deactivation of the endogenous analgesic and anti-inflammatory agent palmitoylethanolamide (PEA). NAAA inhibitors counteract this process and exert marked therapeutic effects in anima...

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Main Authors: Andrea Ghidini (Author), Laura Scalvini (Author), Francesca Palese (Author), Alessio Lodola (Author), Marco Mor (Author), Daniele Piomelli (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
Copy 1 Available