Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase

• Główni autorzy: Andrea Ghidini (Autor), Laura Scalvini (Autor), Francesca Palese (Autor), Alessio Lodola (Autor), Marco Mor (Autor), Daniele Piomelli (Autor)
• Format: Książka
• Wydane: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

N-acylethanolamine acid amidase (NAAA) is an N-terminal nucleophile (Ntn) hydrolase that catalyses the intracellular deactivation of the endogenous analgesic and anti-inflammatory agent palmitoylethanolamide (PEA). NAAA inhibitors counteract this process and exert marked therapeutic effects in anima...