Standard procedures for blood withdrawal in conscious male rats induce stress and profoundly affect glucose tolerance and secretion of glucoregulatory hormones

• Main Authors: Kent Pedersen (Author), Helle Andersen (Author), Christian Fledelius (Author), Jens Juul Holst (Author), Sara Toftegaard Hjuler (Author), Rune Ehrenreich Kuhre (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: A fundamental difference between physiological and pharmacological studies in rats and humans is that withdrawal of blood from conscious rats necessitates restraint which inevitably inflicts a higher level of stress. We investigated the impact of handling on acute glucose regulation and s...