Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR

• Main Authors: Fangfang Wang (Author), Sora Jin (Author), Franklin Mayca Pozo (Author), Danmei Tian (Author), Xiyang Tang (Author), Yi Dai (Author), Xinsheng Yao (Author), Jinshan Tang (Author), Youwei Zhang (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA damage response (DDR) is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs. Hence, small molecules that inhibit DDR are expected to enhance the anti-cancer effect of chemotherapy. Through a recent chemical library screen, we...