Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR

• Asıl Yazarlar: Fangfang Wang (Yazar), Sora Jin (Yazar), Franklin Mayca Pozo (Yazar), Danmei Tian (Yazar), Xiyang Tang (Yazar), Yi Dai (Yazar), Xinsheng Yao (Yazar), Jinshan Tang (Yazar), Youwei Zhang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2022-03-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

DNA damage response (DDR) is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs. Hence, small molecules that inhibit DDR are expected to enhance the anti-cancer effect of chemotherapy. Through a recent chemical library screen, we...