Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone's Particle Size on Sustained Release

• Autori principali: Anna Nardi-Ricart (Autore), Isaac Nofrerias-Roig (Autore), Marc Suñé-Pou (Autore), Pilar Pérez-Lozano (Autore), Montse Miñarro-Carmona (Autore), Encarna García-Montoya (Autore), Josep R. Ticó-Grau (Autore), Raul Insa Boronat (Autore), Josep M. Suñé-Negre (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2020-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-<i>O</i>-methyl transferase. In recent years, it has been shown that tolcapone is a pot...