Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone's Particle Size on Sustained Release

• Hoofdauteurs: Anna Nardi-Ricart (Auteur), Isaac Nofrerias-Roig (Auteur), Marc Suñé-Pou (Auteur), Pilar Pérez-Lozano (Auteur), Montse Miñarro-Carmona (Auteur), Encarna García-Montoya (Auteur), Josep R. Ticó-Grau (Auteur), Raul Insa Boronat (Auteur), Josep M. Suñé-Negre (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2020-07-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-<i>O</i>-methyl transferase. In recent years, it has been shown that tolcapone is a pot...