Formulation of Sustained Release Hydrophilic Matrix Tablets of Tolcapone with the Application of Sedem Diagram: Influence of Tolcapone's Particle Size on Sustained Release

• Main Authors: Anna Nardi-Ricart (Author), Isaac Nofrerias-Roig (Author), Marc Suñé-Pou (Author), Pilar Pérez-Lozano (Author), Montse Miñarro-Carmona (Author), Encarna García-Montoya (Author), Josep R. Ticó-Grau (Author), Raul Insa Boronat (Author), Josep M. Suñé-Negre (Author)
• Format: Book
• Published: MDPI AG, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hydrophilic matrix tablets are a type of sustained release dosage form characterized by distributing a drug in a matrix that is usually polymeric. Tolcapone is a drug that inhibits the enzyme catechol-<i>O</i>-methyl transferase. In recent years, it has been shown that tolcapone is a pot...