l-Glutamate Enhances Methylmercury Toxicity by Synergistically Increasing Oxidative Stress

• Main Authors: Sirirat Amonpatumrat (Author), Hiroyuki Sakurai (Author), Pattama Wiriyasermkul (Author), Narakorn Khunweeraphong (Author), Shushi Nagamori (Author), Hidekazu Tanaka (Author), Pawinee Piyachaturawat (Author), Yoshikatsu Kanai (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Methylmercury (MeHg) is a well-known environmental toxicant. With its lipophilic nature and high reactivity to sulfhydryl groups, it is widely distributed and accumulated in the body to damage cells. Oxidative stress is proposed as a major mechanism underlying the cytotoxic action of MeHg. In the pr...