Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

Formation of the reactive amodiaquine quinoneimine (AQ-QI) and N-desethylamodiaquine quinoneimine (DEAQ-QI) plays an important role in the toxicity of the anti-malaria drug amodiaquine (AQ). Glutathione conjugation protects against AQ-induced toxicity and GSTP1 is able to conjugate its quinoneimine...

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Main Authors: Yongjie Zhang (Author), Shalenie P. den Braver-Sewradj (Author), Michiel W. den Braver (Author), Steven Hiemstra (Author), Nico P. E. Vermeulen (Author), Bob van de Water (Author), Jan N. M. Commandeur (Author), J. C. Vos (Author)
Format: Book
Published: Frontiers Media S.A., 2018-04-01T00:00:00Z.
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3rd Floor Main Library

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