Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

• Main Authors: Yongjie Zhang (Author), Shalenie P. den Braver-Sewradj (Author), Michiel W. den Braver (Author), Steven Hiemstra (Author), Nico P. E. Vermeulen (Author), Bob van de Water (Author), Jan N. M. Commandeur (Author), J. C. Vos (Author)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2018-04-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Formation of the reactive amodiaquine quinoneimine (AQ-QI) and N-desethylamodiaquine quinoneimine (DEAQ-QI) plays an important role in the toxicity of the anti-malaria drug amodiaquine (AQ). Glutathione conjugation protects against AQ-induced toxicity and GSTP1 is able to conjugate its quinoneimine...