Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine

• Main Authors: Sean R. Moore (Author), Jill Pruszka (Author), Jefferson Vallance (Author), Eitaro Aihara (Author), Toru Matsuura (Author), Marshall H. Montrose (Author), Noah F. Shroyer (Author), Christian I. Hong (Author)
• Format: Book
• Published: The Company of Biologists, 2014-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Disruption of circadian rhythms is a risk factor for several human gastrointestinal (GI) diseases, ranging from diarrhea to ulcers to cancer. Four-dimensional tissue culture models that faithfully mimic the circadian clock of the GI epithelium would provide an invaluable tool to understand circadian...