Incomplete Suppression of HIV-1 by SAMHD1 Permits Efficient Macrophage Infection
Background: Sterile alpha motif and histidine/aspartic acid domain-containing protein (SAMHD1) is a dNTP triphosphorylase that reduces cellular dNTP levels in non-dividing cells, such as macrophages. Since dNTPs are required for reverse transcription, HIV-2 and most SIVs encode a Vpx protein that pr...
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| Main Authors: | , , , , |
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| Format: | Book |
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Case Western Reserve University,
2018-12-01T00:00:00Z.
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