Impaired neural differentiation and glymphatic CSF flow in the Ccdc39 rat model of neonatal hydrocephalus: genetic interaction with L1cam

• Main Authors: A. Scott Emmert (Author), Eri Iwasawa (Author), Crystal Shula (Author), Preston Schultz (Author), Diana Lindquist (Author), R. Scott Dunn (Author), Elizabeth M. Fugate (Author), Yueh-Chiang Hu (Author), Francesco T. Mangano (Author), June Goto (Author)
• Format: Book
• Published: The Company of Biologists, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neonatal hydrocephalus affects about one child per 1000 births and is a major congenital brain abnormality. We previously discovered a gene mutation within the coiled-coil domain-containing 39 (Ccdc39) gene, which causes the progressive hydrocephalus (prh) phenotype in mice due to lack of ependymal-...