Focal adhesion kinase inhibition decreases cell viability and induces apoptosis of JAK2 V617F positive cells

• Main Authors: Ana Carolina Menezes Mendonça Valente (Author), Gustavo Henrique Lima de Farias (Author), Ana Cristina Ribeiro Bernardo (Author), Caio Cesar de Souza Alves (Author), Michelle Bueno de Moura Pereira (Author), Raquel Tognon-Ribeiro (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Focal Adhesion Kinase (FAK) protein participates in proliferation, migration, cell survival, and apoptosis process. It has been described as overexpressed in several neoplasms being a promising target for therapy. BCR-ABL negative chronic Myeloproliferative Neoplasms (MPN) are clonal disord...