Focal adhesion kinase inhibition decreases cell viability and induces apoptosis of JAK2 V617F positive cells

• Κύριοι συγγραφείς: Ana Carolina Menezes Mendonça Valente (Συγγραφέας), Gustavo Henrique Lima de Farias (Συγγραφέας), Ana Cristina Ribeiro Bernardo (Συγγραφέας), Caio Cesar de Souza Alves (Συγγραφέας), Michelle Bueno de Moura Pereira (Συγγραφέας), Raquel Tognon-Ribeiro (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Universidade de São Paulo, 2023-08-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Abstract Focal Adhesion Kinase (FAK) protein participates in proliferation, migration, cell survival, and apoptosis process. It has been described as overexpressed in several neoplasms being a promising target for therapy. BCR-ABL negative chronic Myeloproliferative Neoplasms (MPN) are clonal disord...