Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C9*72-*75 in the Chinese Han population

• Main Authors: Fang-Ling Zhao (Author), Qing Zhang (Author), Shuang-Hu Wang (Author), Yun Hong (Author), Shan Zhou (Author), Quan Zhou (Author), Pei-Wu Geng (Author), Qing-Feng Luo (Author), Jie-Fu Yang (Author), Hao Chen (Author), Jian-Ping Cai (Author), Da-Peng Dai (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cytochrome 2C9 (CYP2C9), one of the most important drug metabolic enzymes in the human hepatic P450 superfamily, is required for the metabolism of 15% of clinical drugs. Similar to other CYP2C family members, CYP2C9 gene has a high genetic polymorphism which can cause significant racial and inter-in...