Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C9*72-*75 in the Chinese Han population

• Autori principali: Fang-Ling Zhao (Autore), Qing Zhang (Autore), Shuang-Hu Wang (Autore), Yun Hong (Autore), Shan Zhou (Autore), Quan Zhou (Autore), Pei-Wu Geng (Autore), Qing-Feng Luo (Autore), Jie-Fu Yang (Autore), Hao Chen (Autore), Jian-Ping Cai (Autore), Da-Peng Dai (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Cytochrome 2C9 (CYP2C9), one of the most important drug metabolic enzymes in the human hepatic P450 superfamily, is required for the metabolism of 15% of clinical drugs. Similar to other CYP2C family members, CYP2C9 gene has a high genetic polymorphism which can cause significant racial and inter-in...